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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6553
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pubmed:dateCreated |
1995-12-14
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pubmed:databankReference |
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pubmed:abstractText |
The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xnot protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
378
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
150-7
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pubmed:dateRevised |
2009-9-29
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pubmed:meshHeading |
pubmed-meshheading:7477317-Amino Acid Sequence,
pubmed-meshheading:7477317-Animals,
pubmed-meshheading:7477317-Base Sequence,
pubmed-meshheading:7477317-Cell Differentiation,
pubmed-meshheading:7477317-Chromosome Mapping,
pubmed-meshheading:7477317-DNA Primers,
pubmed-meshheading:7477317-DNA-Binding Proteins,
pubmed-meshheading:7477317-Gastrula,
pubmed-meshheading:7477317-Genes, Homeobox,
pubmed-meshheading:7477317-Genes, Lethal,
pubmed-meshheading:7477317-Hedgehog Proteins,
pubmed-meshheading:7477317-Homeodomain Proteins,
pubmed-meshheading:7477317-Humans,
pubmed-meshheading:7477317-Mesoderm,
pubmed-meshheading:7477317-Molecular Sequence Data,
pubmed-meshheading:7477317-Motor Neurons,
pubmed-meshheading:7477317-Mutation,
pubmed-meshheading:7477317-Notochord,
pubmed-meshheading:7477317-Proteins,
pubmed-meshheading:7477317-RNA, Messenger,
pubmed-meshheading:7477317-Stem Cells,
pubmed-meshheading:7477317-Tail,
pubmed-meshheading:7477317-Trans-Activators,
pubmed-meshheading:7477317-Transcription Factors,
pubmed-meshheading:7477317-Xenopus Proteins,
pubmed-meshheading:7477317-Zebrafish,
pubmed-meshheading:7477317-Zebrafish Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
A homeobox gene essential for zebrafish notochord development.
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pubmed:affiliation |
Institute of Neuroscience, University of Oregon, Eugene 97403, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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