Linked Life Data

7476585

Source:http://linkedlifedata.com/resource/pubmed/id/7476585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-12-20
pubmed:abstractText
Feedback from mechanoreceptors in the lungs to the brainstem has long been known to be vital for control of rhythmogenesis during normal breathing. Action potentials transmitted via the vagi are shown to display an irreversible relationship with respect to lung area (A), i.e. hysteresis, which closely resembles the hysteresis in surface tension (gamma) versus A for normal surfactant which coats that surface. Since lung recoil is largely determined by surface tension for resting tidal volumes, this will dominate the stretch of mechanoreceptors. Hence, it is postulated that, through the Hering-Breuer reflex, surfactant largely determines afferent neural feedback, explaining the above similarity in clockwise hysteresis loops. Thus the ability of normal surfactant to impart normal clockwise gamma: A hysteresis is seen as a desirable property enabling the brainstem to differentiate between the inspiratory and expiratory phases of the breathing cycle at the same lung volume. It is further hypothesized that the very abnormal surfactant found recently in some infants with prolonged expiratory apnoea by displaying anti-clockwise gamma: A loops would render afferent neural feedback to the brainstem highly confusing and could cause prolonged expiratory apnoea. This concept is discussed as a possible cause of sleep apnoea, recurrent cyanotic episodes and the Sudden Infant Death Syndrome (SIDS).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0306-9877
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A novel role for surfactant in the lung with implications for the sudden infant death syndrome.
pubmed:affiliation
Paediatric Respiratory Research Centre, Mater Children's Hospital, South Brisbane, Queensland, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't