Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-12-4
pubmed:abstractText
Several multi-dimensional statistical evaluation methods were applied to single-voxel proton MR spectra of glial brain tumors and of healthy volunteers. Metabolic coordinates with histological relevance for future diagnosis were found by which spectra from controls, low-grade tumors, and high-grade tumors were completely separated. Significant differences between low-grade and high-grade glioma patients and controls were found for several metabolic ratios by variance analysis. Cluster analysis both with and without principal component analysis was applied. The outcome of these two approaches depended mainly on the lipid-to-creatine ratio. Two other approaches, discriminant factor analysis and the orthonormal discriminant vector method were then used to find discriminatory metabolic coordinates. It turned out that a linear combination of all evaluable metabolic ratios made it possible to separate the three groups completely. On the basis of these results, a classification method that uses the entire proton MRS spectrum is proposed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
242-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7476084-Adult, pubmed-meshheading:7476084-Aspartic Acid, pubmed-meshheading:7476084-Astrocytoma, pubmed-meshheading:7476084-Brain Neoplasms, pubmed-meshheading:7476084-Choline, pubmed-meshheading:7476084-Cluster Analysis, pubmed-meshheading:7476084-Creatine, pubmed-meshheading:7476084-Discriminant Analysis, pubmed-meshheading:7476084-Female, pubmed-meshheading:7476084-Glioblastoma, pubmed-meshheading:7476084-Glioma, pubmed-meshheading:7476084-Glutamates, pubmed-meshheading:7476084-Glutamine, pubmed-meshheading:7476084-Glycine, pubmed-meshheading:7476084-Humans, pubmed-meshheading:7476084-Hydrogen, pubmed-meshheading:7476084-Inositol, pubmed-meshheading:7476084-Lipid Metabolism, pubmed-meshheading:7476084-Magnetic Resonance Spectroscopy, pubmed-meshheading:7476084-Male, pubmed-meshheading:7476084-Middle Aged, pubmed-meshheading:7476084-Oligodendroglioma, pubmed-meshheading:7476084-Protons
pubmed:year
1995
pubmed:articleTitle
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
pubmed:affiliation
MR Center, University, Basel, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't