Linked Life Data

7474874

Source:http://linkedlifedata.com/resource/pubmed/id/7474874

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-12-7
pubmed:abstractText
Experimentally induced infection with high doses of Mycoplasma pulmonis results in acute pneumonia characterized by severe pulmonary hemorrhage, edema, and, often, death in C3H/HeN mice. To determine whether specific disease manifestations were associated with coagulopathy, we measured serum fibrin, fibrinogen degradation products, and plasma fibrinogen concentrations in C3H/HeN mice infected with high doses of a virulent strain of M. pulmonis. We also examined the lungs and other tissues from infected mice for the presence of intravascular fibrin clots and other lesions. Increased concentrations of fibrinogen degradation products indicated that coagulopathy occurs in acute M. pulmonis infection; however, intravascular fibrin clots were not present. Rather than decreasing, as might be expected during a consumptive coagulopathy, fibrinogen concentrations increased. The hyperfibrinogenemia probably is associated with an acute phase response to M. pulmonis infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0023-6764
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
368-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Acute Mycoplasma pulmonis infection associated with coagulopathy in C3H/HeN mice.
pubmed:affiliation
Department of Comparative Medicine, School of Medicine, University of Alabama at Birmingham, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.