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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1995-12-13
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pubmed:abstractText |
To determine whether the effects of topically administered timolol in an individual would be dependent on the presence or absence in that individual of the P-450 enzyme CYP2D6 and whether the effects of topically administered timolol would be increased and its metabolism decreased by the oral administration of quinidine, a known inhibitor of CYP2D6.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0098-7484
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1611-3
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:7474246-Administration, Oral,
pubmed-meshheading:7474246-Administration, Topical,
pubmed-meshheading:7474246-Adrenergic beta-Antagonists,
pubmed-meshheading:7474246-Adult,
pubmed-meshheading:7474246-Cross-Over Studies,
pubmed-meshheading:7474246-Cytochrome P-450 CYP2D6,
pubmed-meshheading:7474246-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7474246-Debrisoquin,
pubmed-meshheading:7474246-Drug Interactions,
pubmed-meshheading:7474246-Enzyme Inhibitors,
pubmed-meshheading:7474246-Exercise Test,
pubmed-meshheading:7474246-Heart Rate,
pubmed-meshheading:7474246-Humans,
pubmed-meshheading:7474246-Male,
pubmed-meshheading:7474246-Mixed Function Oxygenases,
pubmed-meshheading:7474246-Ophthalmic Solutions,
pubmed-meshheading:7474246-Phenotype,
pubmed-meshheading:7474246-Quinidine,
pubmed-meshheading:7474246-Single-Blind Method,
pubmed-meshheading:7474246-Timolol
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pubmed:articleTitle |
Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction.
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pubmed:affiliation |
Department of Pharmacology, Meharry Medical College, Nashville, Tenn, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
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