Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1995-12-15
pubmed:abstractText
Treatment of congenital diaphragmatic hernia (CDH) has undergone a revolutionary change in philosophy, from previous urgent repair to the present practice of stabilization and delayed repair. However, when extracorporeal membrane oxygenation (ECMO) is required, many people believe that the risk of postoperative pulmonary hypertension (PPHN) mandates hernia repair while on ECMO. This report details the experience in two ECMO centers with stabilization, ECMO if required, and CDH repair post-ECMO. All CDH patients symptomatic in the first hour of life with a gestational age of at least 34 weeks during the period were reviewed retrospectively. Standard criteria were used to select patients for ECMO. High-frequency jet or oscillating ventilators and nitric oxide were not routinely available throughout the study period, but were used in some of the more recent patients. A total of 60 patients presented to the two centers; 24 cases were stabilized with conventional management, repair of the CDH was done elective, and survival was 100%. Eight patients were referred after having repair elsewhere; six survived (75%). The two deaths were attributable to associated lethal lesions--complex cyanotic heart disease and alveolar capillary dysplasia. Eight patients who required ECMO were managed with the intention of repairing the defect on ECMO. Four survived (50%). Two patients died before repair. Twenty patients were managed with ECMO, with the intention of repairing the defect after decannulation. Overall survival was 13 (65%), deaths were caused by pre-ECMO hypoxia, pulmonary insufficiency, and associated cardiac disease. No patient had recurrent pulmonary hypertension after late repair.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3468
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1183-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:7472978-Anoxia, pubmed-meshheading:7472978-Capillaries, pubmed-meshheading:7472978-Cause of Death, pubmed-meshheading:7472978-Cyanosis, pubmed-meshheading:7472978-Extracorporeal Membrane Oxygenation, pubmed-meshheading:7472978-Gestational Age, pubmed-meshheading:7472978-Heart Defects, Congenital, pubmed-meshheading:7472978-Hernia, Diaphragmatic, pubmed-meshheading:7472978-High-Frequency Jet Ventilation, pubmed-meshheading:7472978-Humans, pubmed-meshheading:7472978-Hypertension, Pulmonary, pubmed-meshheading:7472978-Infant, Newborn, pubmed-meshheading:7472978-Nitric Oxide, pubmed-meshheading:7472978-Oxygen, pubmed-meshheading:7472978-Philosophy, Medical, pubmed-meshheading:7472978-Postoperative Complications, pubmed-meshheading:7472978-Pulmonary Alveoli, pubmed-meshheading:7472978-Respiratory Insufficiency, pubmed-meshheading:7472978-Retrospective Studies, pubmed-meshheading:7472978-Surgical Procedures, Elective, pubmed-meshheading:7472978-Survival Rate, pubmed-meshheading:7472978-Time Factors, pubmed-meshheading:7472978-Ventilators, Mechanical
pubmed:year
1995
pubmed:articleTitle
Timing of repair of congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation support.
pubmed:affiliation
Department of Surgery, Royal Alexandra Hospital, University of Alberta, Edmonton.
pubmed:publicationType
Journal Article