Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1995-12-4
|
| pubmed:abstractText |
The current management of pediatric vaginal and vulvar rhabdomyosarcoma (RMS) uses cytoreductive chemotherapy before surgical intervention. During the Intergroup Rhabdomyosarcoma Study (IRS)-III (1984 to 1988), 27 evaluable patients were entered on a preoperative chemotherapy protocol. Among 24 patients with vaginal primaries, 20 had an initial biopsy with gross residual (group III), 3 had resection with positive margins (group IIA) and 1 had metastatic disease (group IV). At subsequent surgery, 7 patients underwent partial or complete vaginectomy and 6 of them had no viable tumor identified in the specimen. Only 1 of these 7 patients underwent a cystectomy, whereas 5 underwent hysterectomy. Seventeen patients in this group have no evidence of disease 66 to 108 months after diagnosis; 2 died of chemotoxicity and 1 of unknown causes after achieving a complete response. Ten of these 17 patients were treated with biopsy and chemotherapy only. Four of these 10 had radiotherapy as well. All group IIA patients have no evidence of disease. The 1 group IV patient had rapidly progressive disease with early death. This primary chemotherapy protocol resulted in less need for operative intervention or irradiation compared with previous experience. There was no local recurrence, and 20 of 24 patients remain continuously relapse-free with no evidence of disease. All 3 patients with vulvar primaries were treated by wide local excision and chemotherapy and have no evidence of disease. Conservative surgical intervention for vaginal RMS with primary chemotherapy and adjunctive radiation when necessary appears to result in excellent disease-free survival.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-3468
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1034-6; discussion 1036-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7472927-Adolescent,
pubmed-meshheading:7472927-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7472927-Cause of Death,
pubmed-meshheading:7472927-Child,
pubmed-meshheading:7472927-Child, Preschool,
pubmed-meshheading:7472927-Combined Modality Therapy,
pubmed-meshheading:7472927-Cystectomy,
pubmed-meshheading:7472927-Disease-Free Survival,
pubmed-meshheading:7472927-Female,
pubmed-meshheading:7472927-Humans,
pubmed-meshheading:7472927-Hysterectomy,
pubmed-meshheading:7472927-Infant,
pubmed-meshheading:7472927-Neoplasm, Residual,
pubmed-meshheading:7472927-Neoplasm Recurrence, Local,
pubmed-meshheading:7472927-Radiotherapy, Adjuvant,
pubmed-meshheading:7472927-Remission Induction,
pubmed-meshheading:7472927-Reoperation,
pubmed-meshheading:7472927-Rhabdomyosarcoma,
pubmed-meshheading:7472927-Treatment Outcome,
pubmed-meshheading:7472927-Vagina,
pubmed-meshheading:7472927-Vaginal Neoplasms,
pubmed-meshheading:7472927-Vulvar Neoplasms
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Conservative surgical management of vaginal and vulvar pediatric rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study III.
|
| pubmed:affiliation |
Intergroup Rhabdomyosarcoma Study Committee of the Pediatric Oncology Group, Houston, TX, USA.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
|