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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-12-12
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pubmed:abstractText |
Feeding rats with a diet containing 0.25% clofibrate for 2 weeks elevated the hepatic NAD+ and total nicotinate levels significantly. Other peroxisome proliferators, such as 2-(4-chlorophenoxy)propionic acid and di(2-ethylhexyl)phthalate, had similar effects. When rats were fed the control diet without clofibrate for 1 week after 2 weeks of the clofibrate diet, the hepatic NAD+ level returned to the control value. Muscular NAD+ content was not affected by the peroxisome proliferators. The results were discussed in relation to induction of peroxisomal beta-oxidation enzymes by the peroxisome proliferators.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0301-4800
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7472678-Animals,
pubmed-meshheading:7472678-Clofibrate,
pubmed-meshheading:7472678-Diet,
pubmed-meshheading:7472678-Diethylhexyl Phthalate,
pubmed-meshheading:7472678-Fenofibrate,
pubmed-meshheading:7472678-Hypolipidemic Agents,
pubmed-meshheading:7472678-Liver,
pubmed-meshheading:7472678-Male,
pubmed-meshheading:7472678-Microbodies,
pubmed-meshheading:7472678-NAD,
pubmed-meshheading:7472678-Rats,
pubmed-meshheading:7472678-Rats, Sprague-Dawley
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pubmed:year |
1995
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pubmed:articleTitle |
Effect of feeding clofibrate-containing diet on the hepatic NAD+ level in rats.
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pubmed:affiliation |
School of Pharmacy, Kobe Gakuin University, Japan.
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pubmed:publicationType |
Journal Article
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