| pubmed-article:7472500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C0597694 | lld:lifeskim |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C0140057 | lld:lifeskim |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C0178702 | lld:lifeskim |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7472500 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:7472500 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7472500 | pubmed:dateCreated | 1995-12-26 | lld:pubmed |
| pubmed-article:7472500 | pubmed:abstractText | We have developed the coexpression system of both delta-opioid receptor (DOR1) and M2-muscarinic receptor (M2) which mediate agonist-evoked currents due to common post-receptor mechanisms including Gi1 and phospholipase C (PLC) activation in Xenopus oocytes reconstituted with Gi1 alpha. The DOR1-currents by 100 nM D-Ser2-leu-enkephalin-Thr6 (DSLET) were selectively desensitized by 10 nM phorbol 12-myristate 13-acetate (PMA). The PMA-desensitization of DSLET-currents was abolished in the presence of calphostin C, a protein kinase C inhibitor, or reversed by an intracellular injection of calcineurin, a protein phosphatase 2B. When a higher concentration (3 microM) of DSLET was used, DSLET-currents were rapidly desensitized by repeated challenges of DSLET itself. However, repeated challenges of 10 microM ACh caused no influence on such DSLET- or M2-currents. The desensitization of DSLET-currents was selectively reversed by protein kinase C inhibitors. Similar results were also obtained with various delta-opioid agonists. These results suggest that protein kinase C is involved in the homologous desensitization of delta-opioid receptors. | lld:pubmed |
| pubmed-article:7472500 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7472500 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7472500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7472500 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7472500 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:WatanabeSS | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:FukushimaNN | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:SasakiYY | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:UedaHH | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:MiyamaeTT | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:HayashiCC | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:MisuYY | lld:pubmed |
| pubmed-article:7472500 | pubmed:author | pubmed-author:IwamuraTT | lld:pubmed |
| pubmed-article:7472500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7472500 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:7472500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7472500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7472500 | pubmed:pagination | 7485-99 | lld:pubmed |
| pubmed-article:7472500 | pubmed:dateRevised | 2008-8-22 | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
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| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:meshHeading | pubmed-meshheading:7472500-... | lld:pubmed |
| pubmed-article:7472500 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7472500 | pubmed:articleTitle | Protein kinase C involvement in homologous desensitization of delta-opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes. | lld:pubmed |
| pubmed-article:7472500 | pubmed:affiliation | Department of Pharmacology, Yokohama City University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:7472500 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7472500 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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