Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1995-12-26
|
| pubmed:abstractText |
We studied the effects of serotonin (5-HT) on intrinsic and synaptic responses of hippocampal CA1 cells. The effects were partially mimicked by the 5-HT1A receptor agonist, 8-OH-DPAT, and prevented by the 5-HT1A receptor antagonist, NAN-190. Polysynaptic fast and slow inhibitory postsynaptic potentials (IPSPs) were reduced in amplitude by 60-70% following application of both 5-HT and 8-OH-DPAT. Monosynaptic fast IPSPs were reduced by 60% and slow IPSPs by 90% following application of both drugs. Since there is a temporal overlap of fast and slow IPSPs, the reduction in fast IPSPs could have arisen indirectly from the larger effect of 5-HT on slow IPSPs. To overcome this problem we blocked the slow IPSPs with new, potent GABA-B antagonists, but still observed a similar reduction in the fast IPSP with 5-HT and 8-OH-DPAT. However, the reductions in the fast IPSPs could also have arisen from the 5-HT-induced total conductance increases. Using single-electrode voltage clamp and intracellular K+ channel blockers we still observed similar changes. 5-HT and 8-OH-DPAT had no effect upon GABA-A-mediated currents evoked by iontophoretic GABA application to the dendrites or the soma of CA1 pyramidal cells, Putative inhibitory internuerons were hyperpolarized by 5-HT and their evoked EPSPs strongly reduced by 5-HT and 8-OH-DPAT. Our data indicate that 5-HT modulates fast and slow synaptic inhibition of principal cells using presynaptic mechanisms involving the inhibition of inhibitory interneurons.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(2-methoxyphenyl)-4-(4-(2-phthalim...,
http://linkedlifedata.com/resource/pubmed/chemical/8-Hydroxy-2-(di-n-propylamino)tetral...,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0270-6474
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
7217-25
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7472476-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:7472476-Animals,
pubmed-meshheading:7472476-Electric Conductivity,
pubmed-meshheading:7472476-Female,
pubmed-meshheading:7472476-Hippocampus,
pubmed-meshheading:7472476-Interneurons,
pubmed-meshheading:7472476-Neural Inhibition,
pubmed-meshheading:7472476-Neurons,
pubmed-meshheading:7472476-Piperazines,
pubmed-meshheading:7472476-Rats,
pubmed-meshheading:7472476-Rats, Wistar,
pubmed-meshheading:7472476-Receptors, Serotonin,
pubmed-meshheading:7472476-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:7472476-Serotonin,
pubmed-meshheading:7472476-Serotonin Antagonists,
pubmed-meshheading:7472476-Serotonin Receptor Agonists,
pubmed-meshheading:7472476-Synapses,
pubmed-meshheading:7472476-Synaptic Transmission,
pubmed-meshheading:7472476-gamma-Aminobutyric Acid
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro.
|
| pubmed:affiliation |
Institute for Physiology at the Charite, Department of Neurophysiology, Humboldt University Berlin, Germany.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|