Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1995-12-4
pubmed:abstractText
Lesions of the subthalamic nucleus block behavioral effects of nigrostriatal dopamine depletion in rats and primates, but the contribution of this region to the molecular effects of dopaminergic lesions is unknown. The effects of subthalamic nucleus lesions alone or in combination with a 6-hydroxydopamine-induced lesion of the substantia nigra were examined in adult rats. Unilateral subthalamic nucleus lesions caused ipsiversive rotation after peripheral administration of apomorphine and a small decrease in glutamic acid decarboxylase (GAD) mRNA in the ipsilateral globus pallidus (external pallidum). Confirming previous results, nigrostriatal dopaminergic lesions caused contraversive rotation after apomorphine injection, and increased enkephalin mRNA in the striatum, GAD mRNA in the globus pallidus, and somatostatin mRNA in the entopeduncular nucleus (internal pallidum) ipsilateral to the lesion. In addition, the lesion decreased substance P mRNA in the ipsilateral striatum compared to the contralateral side, and GAD mRNA in the contralateral entopeduncular nucleus. These effects were abolished in rats with lesions of the subthalamic nucleus and substantia nigra on the same side. Thus, the subthalamic lesions prevented changes in gene expression induced by dopamine depletion, not only in regions receiving a direct input from the subthalamic nucleus (ipsilateral pallidum), but also in regions which do not (striatum and contralateral pallidum). This suggests that polysynaptic pathways regulated by the subthalamic nucleus contribute to the effects of dopaminergic lesions in many regions of the basal ganglia. This pivotal role of the subthalamic nucleus may account for the beneficial effects of subthalamic nucleus lesions on motor symptoms resulting from dopamine depletion.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6562-75
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7472418-Animals, pubmed-meshheading:7472418-Apomorphine, pubmed-meshheading:7472418-Behavior, Animal, pubmed-meshheading:7472418-Corpus Striatum, pubmed-meshheading:7472418-Dopamine, pubmed-meshheading:7472418-Enkephalins, pubmed-meshheading:7472418-Gene Expression Regulation, pubmed-meshheading:7472418-Globus Pallidus, pubmed-meshheading:7472418-Glutamate Decarboxylase, pubmed-meshheading:7472418-Male, pubmed-meshheading:7472418-Oxidopamine, pubmed-meshheading:7472418-RNA, Messenger, pubmed-meshheading:7472418-Rats, pubmed-meshheading:7472418-Rats, Sprague-Dawley, pubmed-meshheading:7472418-Somatostatin, pubmed-meshheading:7472418-Stereotyped Behavior, pubmed-meshheading:7472418-Substance P, pubmed-meshheading:7472418-Substantia Nigra, pubmed-meshheading:7472418-Thalamic Nuclei
pubmed:year
1995
pubmed:articleTitle
Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rats.
pubmed:affiliation
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.