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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1981-5-13
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pubmed:abstractText |
Disopyramide hemodialysis and kinetics after 200 mg orally in six patients receiving long-term hemodialysis were examined. Mean volume of distribution (area) was 66.5 +/- 13 l. Mean times of the peak serum concentration and mean peak serum concentration were 2.3 +/- 0.9 hr and 3.1 +/- 0.9 microgram/ml. Mean absorption half-life (t 1/2) was 21.6 +/- 12.5 min. Mean disopyramide elimination t 1/2 during dialysis was 16.8 +/- 11.9 hr, not significantly different from mean elimination t 1/2 without dialysis of 16.1 +/- 5.2 hr. End-dialysis bath concentrations of disopyramide showed that not more than 2.4% of the dose was dialyzed during a 2-hr dialysis period. Our data indicate that at therapeutic concentrations disopyramide was not appreciably dialyzed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9236
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
322-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7471602-Adult,
pubmed-meshheading:7471602-Disopyramide,
pubmed-meshheading:7471602-Female,
pubmed-meshheading:7471602-Half-Life,
pubmed-meshheading:7471602-Humans,
pubmed-meshheading:7471602-Kinetics,
pubmed-meshheading:7471602-Male,
pubmed-meshheading:7471602-Middle Aged,
pubmed-meshheading:7471602-Pyridines,
pubmed-meshheading:7471602-Renal Dialysis
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pubmed:year |
1981
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pubmed:articleTitle |
Disopyramide hemodialysis and kinetics in patients requiring long-term hemodialysis.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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