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rdf:type |
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lifeskim:mentions |
umls-concept:C0008046,
umls-concept:C0010762,
umls-concept:C0013227,
umls-concept:C0018966,
umls-concept:C0205054,
umls-concept:C0205246,
umls-concept:C0205263,
umls-concept:C0332120,
umls-concept:C0441712,
umls-concept:C0600157,
umls-concept:C1261381,
umls-concept:C1979928
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pubmed:issue |
3
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pubmed:dateCreated |
1981-4-21
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pubmed:abstractText |
A variety of prophyrinogenic compounds were tested for their effect in ovo on chick-embryo liver microsomal cytochrome P-450 haem concentration and mitochondrial delta-aminolaevulinate synthase activity. With all drugs tested, there was a 30--50% decrease in cytochrome P-450 haem concentration within 1 h of treatment, and this was closely followed by an increase in delta-aminolaevulinate synthase activity. The relationship was independent of the extent of enzyme induction and is consistent with the proposal that drug-mediated destruction of cytochrome P-450 haem is the primary mechanism of induction of delta-aminolaevulinate synthase. After induction, synthesis of delta-aminolaevulinate synthase could be maintained by inhibiting further haem synthesis. These studies suggest that induction of porphyria is a combination of two distinct processes: (a) induction of delta-aminolaevulinate synthase synthesis by destruction of cytochrome P-450 haem and consequent depletion of cellular free haem; (b) maintenance of continued delta-aminolaevulinate synthase synthesis by preventing replenishment of cellular haem either by inhibiting haem synthesis and/or by promoting continuous removal of newly synthesized haem.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-1238396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-13949831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-13949833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-14209971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-223065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-227392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-321458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4108609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4185885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4400522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4413844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4473259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4645552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4674939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-4705342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-486100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-486175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-570840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-571439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-5935350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-6122567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-7470035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-815257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470066-901418
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-26
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:7470066-5-Aminolevulinate Synthetase,
pubmed-meshheading:7470066-Allylisopropylacetamide,
pubmed-meshheading:7470066-Animals,
pubmed-meshheading:7470066-Chick Embryo,
pubmed-meshheading:7470066-Cytochrome P-450 Enzyme System,
pubmed-meshheading:7470066-Deferoxamine,
pubmed-meshheading:7470066-Dicarbethoxydihydrocollidine,
pubmed-meshheading:7470066-Enzyme Induction,
pubmed-meshheading:7470066-Heme,
pubmed-meshheading:7470066-Hemin,
pubmed-meshheading:7470066-Microsomes, Liver,
pubmed-meshheading:7470066-Phenobarbital,
pubmed-meshheading:7470066-Porphyrias,
pubmed-meshheading:7470066-Proadifen
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pubmed:year |
1980
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pubmed:articleTitle |
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
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pubmed:publicationType |
Journal Article
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