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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1981-4-13
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pubmed:abstractText |
Feeding male weanling rats on a vitamin A-deficient diet for 6 weeks resulted in significant increases (44-57%) in glutathione S-aryl-, S-aralkyl- S-alkyl- and S-epoxidetransferase activities in the liver cytosol. Only the S-aralkyl- (27%) and S-alkyltransferase (14%) activities were significantly increased in the kidney as a result of deficiency. There was no effect on any of the pulmonary glutathione S-transferase activities. The increases in hepatic transferase activities were due primarily to increases (25-96%) in the apparent Vmax. There were no changes in the apparant Km of any of the four drug substrates employed. With 3,4-dichloronitrobenzene as the second substrate, the apparent Km for glutathione was increased by over 2-fold in vitamin A-deficient livers as compared with controls. The relationship between these results and enhanced susceptibility to chemical carcinogens in vitamin A deficiency is briefly discussed, and comparison is made between the effects of this nutritional state and pretreatment with drug inducers on the glutathione S-transferases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-1180917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-1191323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-357180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-363262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-4187093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-4348122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-4436300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-4634012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-4808941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-4953591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-5938663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-728202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-760819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-770206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-808217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7470042-830423
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
188
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
889-93
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7470042-Animals,
pubmed-meshheading:7470042-Cytosol,
pubmed-meshheading:7470042-Glutathione Transferase,
pubmed-meshheading:7470042-Kidney,
pubmed-meshheading:7470042-Kinetics,
pubmed-meshheading:7470042-Liver,
pubmed-meshheading:7470042-Lung,
pubmed-meshheading:7470042-Male,
pubmed-meshheading:7470042-Rats,
pubmed-meshheading:7470042-Substrate Specificity,
pubmed-meshheading:7470042-Vitamin A Deficiency
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pubmed:year |
1980
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pubmed:articleTitle |
The effect of vitamin A deficiency on hepatic, renal and pulmonary glutathione S-transferase activities in the rat.
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pubmed:publicationType |
Journal Article
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