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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1981-4-21
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pubmed:abstractText |
Uptake rates of total 14C in fathead minnows (Pimephales promelas) exposed to sublethal concentrations of radiolabeled test compounds followed the order: phenol > 2,4,5-trichlorophenol > p-nitrophenol. Mean whole body 14C concentration factors were 15,800, 1,850, and 180 for phenol, 2,4,5-trichlorophenol, and p-nitrophenol exposures, respectively. Only minor amounts of tissue 14C was parent compound after 28 days of exposure in fish exposed to phenol and p-nitrophenol, while 78.6% of the 14C was parent compound in 2,4,5-trichlorophenol exposed fish. Tissue 14C in fish exposed to 2,4,5-trichlorophenol was eliminated at a faster rate than in fish exposed to phenol or p-nitrophenol. Observed mean 14C depuration half-lives for lower and higher exposures combined were 387, 150, and 12 hours for phenol, p-nitrophenol, and 2,4,5-trichlorophenol, respectively. Parent compound comprised 1.5, 2.7, and 0.7% of total 14C for phenol, 2,4,5-trichlorophenol, and p-nitrophenol, respectively, after 28 days of depuration. The percentage of acetone-unextractable 14C increased from the end of uptake to the end of depuration for phenol and 2,4,5-trichlorophenol, and decreased slightly for p-nitrophenol. 14C contribution from polar metabolites increased relative to total 14C during the depuration phase for 2,4,5-trichlorophenol and p-nitrophenol.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,4,5-trichlorophenol,
http://linkedlifedata.com/resource/pubmed/chemical/4-nitrophenol,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorophenols,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrophenols,
http://linkedlifedata.com/resource/pubmed/chemical/Phenol,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Water
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pubmed:status |
MEDLINE
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pubmed:issn |
0090-4341
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-714
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7469481-Animals,
pubmed-meshheading:7469481-Chlorophenols,
pubmed-meshheading:7469481-Fishes,
pubmed-meshheading:7469481-Kinetics,
pubmed-meshheading:7469481-Lipids,
pubmed-meshheading:7469481-Models, Biological,
pubmed-meshheading:7469481-Nitrophenols,
pubmed-meshheading:7469481-Phenol,
pubmed-meshheading:7469481-Phenols,
pubmed-meshheading:7469481-Water
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pubmed:year |
1980
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pubmed:articleTitle |
Uptake, elimination, and metabolism of three phenols by fathead minnows.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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