Linked Life Data

7464909

Source:http://linkedlifedata.com/resource/pubmed/id/7464909

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5796
pubmed:dateCreated
1981-4-21
pubmed:abstractText
The phagocytic functions of polymorphonuclear leukocytes and mononuclear phagocytes are crucial elements in host defence against a variety of invading microorganisms. Phagocytosis is a highly selective process, requiring specific interactions between the surface of the particle to be ingested and the plasma membrane of the phagocytic cell. The phagocyte can therefore discriminate between 'ingestible' and 'non-ingestible' particles even when the different particles are located in close proximity on the plasma membrane of the phagocytic cell. Previous work has demonstrated that these specific interactions between particle and phagocyte are required not only for the initiation of phagocytosis--that is, attachment of the particle to the phagocytic cells and generation of a signal to trigger phagocyte pseudopod extension--but also for the subsequent progression of pseudopods over the entire surface of the particle. We present evidence here that the continued interactions between phagocyte plasma membrane receptors and particle-bound ligands do not function merely to direct otherwise random phagocyte pseudopod movement, but instead are required for the repeated generation of intracellular phagocytic signals during the entire ingestion process.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
289
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-11
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Phagocytosis requires repeated triggering of macrophage phagocytic receptors during particle ingestion.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't