Linked Life Data

7462770

Source:http://linkedlifedata.com/resource/pubmed/id/7462770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-4-13
pubmed:abstractText
The pattern of in vitro growth of erythroid progenitors in cord blood was assayed by the methyl cellulose culture system. The erythroid nature of colonies in culture was determined by Soret band examination for hemoglobin and by immunofluorescence for specific membrane protein spectrin, as well as by conventional techniques. In contrast to adult blood cultures, we found small but definite erythroid colony growth in the cultures of cord blood progenitors in the absence of added Ep (endogenous erythroid colonies). In addition, in the presence of Ep increased numbers of progenitors were found in cord blood compared with adult blood. Comparison of cultures from newborns, normal adults, anemic adults, and adults with PV and myelofibrosis showed that endogenous erythroid colonies are also found in cultures of patients with PV and myelofibrosis but not in cultures of normal cells and cells from anemic subjects. The physiologic relevance of these endogenous colony-forming cells in newborn blood is unknown; however, we speculate that they may be related to residual extramedullary erythropoiesis at birth.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-2143
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
322-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Characterization of circulating erythroid progenitor cells in human newborn blood.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't