Linked Life Data

7462629

Source:http://linkedlifedata.com/resource/pubmed/id/7462629

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-4-13
pubmed:abstractText
Human endothelial culture supernatant (HECS) contains a factor(s) that enhances the proliferation of hybridoma cells as we reported previously. In the present paper, we found that, in comparison with endothelial cells, their supernatant exerts a much stronger growth-promoting effect on hybridoma cells, which can also be detected earlier. In a confluent culture of endothelial cells, detectable amounts of this factor(s) are produced after 2 hr of incubation, and the production is linear in time for 3 days. The enhancing effect of HECS on the proliferation of hybridoma cells appears to be independent of the concentration of cells in the culture. The activity of HECS is adsorbed to hybridoma or myeloma cells, but not to thymocytes. HECS acts on hybridoma cells by delivering a growth-promoting signal that induces the hybridoma cells to proliferate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1170-3
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Human endothelial culture supernatant (HECS): evidence for a growth-promoting factor binding to hybridoma and myeloma cells.
pubmed:publicationType
Journal Article