Linked Life Data

7462609

Source:http://linkedlifedata.com/resource/pubmed/id/7462609

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-4-13
pubmed:abstractText
The deposition fraction in the respiratory tract of rats were determined experimentally using aerosol 85Srl2 in saline. The dimensions of the particles [MMD 1.63 /+- /+- 0.47 micron, Sg = 1.29] were measured by two independent methods. Rats weighing 200 g were exposed for a period of 60 min [t] in the inhalation apparatus PIANO 3 with a generator according to Lauterbach. From the volume activity [A] of 3 - 11 Bq/litre air a depot of 35-129 kBq was formed in the animals. Spirometric values measured with a modified Jäger ergospirometer were: V = 178.8 /+- 42.9 ml, VT = = 1.18 /+- 0.24 ml. f = 163.1 /+- 28.1 cycles/min. The total amount inhaled [Q] was calculated [Q = V.A.t], the deposited amount [D] was measured by a whole body counter. THe mean deposition fraction was 0.570 /+- 0.052 and was not related either to exposure time or to aerosol activity. In view of the broad validity of the conclusions for aerosols of round-shaped particles, the mean deposition fraction was determined with the help of a mathematical model according to Landahl. The theoretical values amounted to 0.609 [from 0.522 to 0.686]. The good agreement between the mean deposition fractions estimated by two independent methods indicates that on the basis of the probability theory and dimensional analysis, the mathematical model can also be used in humans for simulation deposition as one of the basis foundations for a quantitative evaluation of inhalation risk from any kind of aerosol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0022-1732
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-13
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Aerosol deposition in the respiratory tract of the rat. Experimental results and mathematical modelling.
pubmed:publicationType
Journal Article