Linked Life Data

7460836

Source:http://linkedlifedata.com/resource/pubmed/id/7460836

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-4-24
pubmed:abstractText
PRL levels were measured over 30 days of cyst induction in the rat. Polycystic ovaries (PCO) were induced by dietary incorporation of thiouracil (Thio) for 30 days and injection of 10 IU hCG sc for the last 20 days of the experimental period. Animals were killed at specific intervals 24 hours after the last injection. Ovaries and thyroids were removed and weighed. Sera were analyzed for PRL by RIA. PRL levels increased in animals receiving Thio plus hCG by day 30 compared to animals receiving Thio alone. The increase in PRL in the Thio, hCG-stimulated group coincides with formation of follicular cysts. Administration of bromocriptine (1 mg/day) concurrent with hCG during the last 20 days of Thio-feeding significantly suppressed ovarian weight gain and PCO formation. Serum PRL levels in bromocriptine-treated rats were significantly reduced compared to the PCO group yet were also significantly greater than all control groups at day 30. These findings suggest that PRL is important to the etiology of ovarian cysts in the rat.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1095-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Relationship of polycystic ovary induction to prolactin secretion: prevention of cyst formation by bromocriptine in the rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.