| pubmed-article:7459354 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0008377 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C1550605 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0456205 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0075301 | lld:lifeskim |
| pubmed-article:7459354 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:7459354 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7459354 | pubmed:dateCreated | 1981-4-24 | lld:pubmed |
| pubmed-article:7459354 | pubmed:abstractText | Cultures of L cells and HeLa cells were made resistant to the cytolytic toxin, streptolysin O, by incubating them in the presence of 20 alpha-hydroxycholesterol or 25-hydroxycholesterol. Such cells were also found to be more resistant to the cytotoxic effects of saponin and digitonin, agents known to interact with membrane cholesterol. Sterol synthesis in L cells that had been treated with either of the oxygenated derivatives of cholesterol was reduced by almost 90%, and the free cholesterol content of streptolysin O-resistant HeLa and L cells fell to approx. 50% of control cell levels. Significant recovery of sensitivity to streptolysin O occurred in about 6 h when refractory L cells were incubated in serum or cholesterol. Partial recovery was observed when the cultures were incubated for 24 h in mevalonate or lipid-depleted serum. The results provide further support for the role of membrane cholesterol in the cytotoxic action of streptolysin O on mammalian cells. | lld:pubmed |
| pubmed-article:7459354 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7459354 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7459354 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7459354 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7459354 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:7459354 | pubmed:author | pubmed-author:DuncanJ LJL | lld:pubmed |
| pubmed-article:7459354 | pubmed:author | pubmed-author:BuckinghamLL | lld:pubmed |
| pubmed-article:7459354 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7459354 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:7459354 | pubmed:volume | 603 | lld:pubmed |
| pubmed-article:7459354 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7459354 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7459354 | pubmed:pagination | 278-87 | lld:pubmed |
| pubmed-article:7459354 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:meshHeading | pubmed-meshheading:7459354-... | lld:pubmed |
| pubmed-article:7459354 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7459354 | pubmed:articleTitle | Resistance to streptolysin O in mammalian cells treated with oxygenated derivatives of cholesterol. Cholesterol content of resistant cells and recovery of streptolysin O sensitivity. | lld:pubmed |
| pubmed-article:7459354 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7459354 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7459354 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7459354 | lld:pubmed |
