Linked Life Data

7459259

Source:http://linkedlifedata.com/resource/pubmed/id/7459259

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-4-24
pubmed:abstractText
A comparative study of the cellular composition and ultrastructural features of rat brain tumours produced by early and late passage of neoplastic glial cells was carried out. The cells injected intracerebrally were of a clone neoplastic astrocytes (A15A5) derived from a mixed glioma induced transplacentally by N-ethyl-N-nitrosourea (ENU) in a BD-IX rat. The neoplastic cells were maintained for various lengths of time in vitro and then injected (5 X 10(5) cells) into the left frontal lobe of the brains of syngeneic rats, resulting in a 100% tumour yield. Gliomas produced by cells of earlier passages were less malignant and contained better differentiated astrocytes than those produced by cells of later passages. There were also differences in size, shape, extracellular space, presence of haemorrhage and necrosis, vascularity and invasion of the surrounding tissues. Thus the morphological features of transplanted tumours in vivo correlated well with the in vitro behaviour of neoplastic glial cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-1021
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Morphological analysis of malignancy: a comparative study of transplanted brain tumours.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't