Linked Life Data

7458498

Source:http://linkedlifedata.com/resource/pubmed/id/7458498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1981-3-17
pubmed:abstractText
Inactivation of aminoglycosides by carbenicillin and ticarcillin is a well-recognized in vitro phenomenon. Isolated case reports of in vivo inactivation of gentamicin by either carbenicillin or ticarcillin exist. We report a case of nearly complete in vivo inactivation of gentamicin by both ticarcillin and carbenicillin in the same patient. In the absence of either of the penicillin derivatives, the patient demonstrated predictable plasma concentrations and elimination characteristics of both gentamicin and tobramycin. As in previous reports, the interaction was intensified by high-dose carbenicillin-ticarcillin therapy in the face of underlying renal impairment. When using ticarcillin or carbenicillin along with gentamicin in renally impaired patients, special attention must be paid to both the gentamicin and carbenicillin-ticarcillin doses used and the plasma concentrations obtained.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-9926
pubmed:author
pubmed:issnType
Print
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1668-70
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
In vivo inactivation of gentamicin by carbenicillin and ticarcillin.
pubmed:publicationType
Journal Article, Case Reports