Linked Life Data

7458243

Source:http://linkedlifedata.com/resource/pubmed/id/7458243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-3-24
pubmed:abstractText
Two experiments were carried out to define the effect of repeated anthelmintic treatments with or without repeated infections by H. polygyrus on the receptivity of the mouse to subsequent infections by the same parasite. The aim of the first experiment was to show the effect of these interventions on the future development of host resistance. This experiment did not reveal a marked difference in behaviour between treated or non-treated animals. During the second experiment a modification of the acquisition of resistance during the period of infections and multiple treatments was looked for. It was shown that multiple treatments of the host during the period of immunity markedly improved the mechanisms of defense against a new infection. Any direct action of anthelmintics was ruled out in explaining this mechanism. Two drugs were compared: pyrantel tartrate and levamisole. No difference has been shown between these two drugs. It is possible, however, that the multiple treatments act by enabling a more intense renewal of the parasitic population and therefore by increasing the stimulus initiating protection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-4193
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-93
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Repeated anthelmintic treatments and receptivity of mice to experimental infections with Heligmosomoides polygyrus (Nematospiroides dubius).
pubmed:publicationType
Journal Article