Linked Life Data

7458061

Source:http://linkedlifedata.com/resource/pubmed/id/7458061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-3-24
pubmed:abstractText
To determine whether subjects with mild asthma or seasonal rhinitis have greater bronchomotor responses to sulfur dioxide (SO2) than normal subjects, we undertook a study in 7 asthmatic, 7 atopic, and 7 normal subjects, 23 to 37 yr of age. We measured the change in specific airways resistance (SRaw) provoked by 10 min of breathing 1, 3, and 5 ppm of SO2 delivered by mouthpiece on separate days at least 48 h apart. To assess the significance of parasympathetic pathways in the bronchomotor responses to SO2, we also measured the change in SRaw provoked by 5 ppm of SO2 in 17 of the subjects after they inhaled atropine sulfate aerosol (0.1 mg/kg). We found that in the asthmatic subjects, SRaw increased only at 5 ppm. In the asthmatic group, SRaw increased more than in either of the other groups at 5 ppm (p < 0.005), and was sometimes associated with marked dyspnea requiring bronchodilator therapy. The increases in SRaw produced by inhalation of SO2 were prevented by treatment with atropine in asthmatic and nonasthmatic subjects, which suggested the involvement of parasympathetic pathways. These results indicated that subjects with mild asthma develop bronchoconstriction after exposure to concentrations of SO2 well below currently accepted standards for occupational exposure, and that SO2-induced bronchoconstriction is mediated by parasympathetic pathways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0003-0805
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
873-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't