| pubmed-article:7449299 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7449299 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:7449299 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:7449299 | pubmed:dateCreated | 1981-3-27 | lld:pubmed |
| pubmed-article:7449299 | pubmed:abstractText | 1. Sixteen neurosurgical patients received (oral) beta-adrenoreceptor-blocking agents (beta-receptor blockers) for 3-22 days. 2. Lipophilic beta-receptor blockers (propranolol) and metoprolol appeared in cerebrospinal fluid at concentrations similar to the free drug plasma concentration. 3. Cerebrospinal fluid concentrations of beta-receptor blockers were poor predictors of brain concentrations. 4. Both lipophilic beta-receptor blockers appeared in high concentrations in the brain: the brain/plasma ratio was approximately 15:1. 5. Hydrophilic atenolol appeared at low concentrations in brain tissue (about 20 times lower than the lipophilic beta-receptor blockers): the brain/plasma ratio was approximately 0.1:1. 6. Central nervous system-related side effects associated mainly with lipophilic beta-receptor blockers possibly result from high brain tissue concentrations. | lld:pubmed |
| pubmed-article:7449299 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7449299 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7449299 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7449299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7449299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7449299 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7449299 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7449299 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7449299 | pubmed:issn | 0143-5221 | lld:pubmed |
| pubmed-article:7449299 | pubmed:author | pubmed-author:CameronM MMM | lld:pubmed |
| pubmed-article:7449299 | pubmed:author | pubmed-author:McAinshJJ | lld:pubmed |
| pubmed-article:7449299 | pubmed:author | pubmed-author:CruickshankJ... | lld:pubmed |
| pubmed-article:7449299 | pubmed:author | pubmed-author:Neil-DwyerGG | lld:pubmed |
| pubmed-article:7449299 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7449299 | pubmed:volume | 59 Suppl 6 | lld:pubmed |
| pubmed-article:7449299 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7449299 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7449299 | pubmed:pagination | 453s-455s | lld:pubmed |
| pubmed-article:7449299 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:meshHeading | pubmed-meshheading:7449299-... | lld:pubmed |
| pubmed-article:7449299 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7449299 | pubmed:articleTitle | beta-Adrenoreceptor-blocking agents and the blood-brain barrier. | lld:pubmed |
| pubmed-article:7449299 | pubmed:publicationType | Journal Article | lld:pubmed |
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