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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1981-3-27
|
| pubmed:abstractText |
1. Sixteen neurosurgical patients received (oral) beta-adrenoreceptor-blocking agents (beta-receptor blockers) for 3-22 days. 2. Lipophilic beta-receptor blockers (propranolol) and metoprolol appeared in cerebrospinal fluid at concentrations similar to the free drug plasma concentration. 3. Cerebrospinal fluid concentrations of beta-receptor blockers were poor predictors of brain concentrations. 4. Both lipophilic beta-receptor blockers appeared in high concentrations in the brain: the brain/plasma ratio was approximately 15:1. 5. Hydrophilic atenolol appeared at low concentrations in brain tissue (about 20 times lower than the lipophilic beta-receptor blockers): the brain/plasma ratio was approximately 0.1:1. 6. Central nervous system-related side effects associated mainly with lipophilic beta-receptor blockers possibly result from high brain tissue concentrations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0143-5221
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
59 Suppl 6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
453s-455s
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7449299-Atenolol,
pubmed-meshheading:7449299-Blood-Brain Barrier,
pubmed-meshheading:7449299-Brain,
pubmed-meshheading:7449299-Humans,
pubmed-meshheading:7449299-Kinetics,
pubmed-meshheading:7449299-Metoprolol,
pubmed-meshheading:7449299-Propanolamines,
pubmed-meshheading:7449299-Propranolol
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
beta-Adrenoreceptor-blocking agents and the blood-brain barrier.
|
| pubmed:publicationType |
Journal Article
|