Linked Life Data

744928

Source:http://linkedlifedata.com/resource/pubmed/id/744928

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1979-5-23
pubmed:abstractText
Prepubertal (immature) and mature female rabbits were actively immunized against testosterone-3-oxime-bovine serum albumin over a period of 11 weeks. The antibody titre was significant in all animals by 5 weeks. The concentration of FSH in prepubertal animals decreased significantly (P less than 0.001) between weeks 1 and 5, but no significant changes were observed in the concentration of LH at any time. After immunization for 8 weeks, there was a significant (P less than 0.05) increase in the serum concentration of androgen and the percentage of bound testosterone also increased (P less than 0.05). The serum concentration of oestradiol increased after immunization for 11 weeks, compared with values at 8 weeks (P less than 0.05) and oestradiol binding also rose by week 5 (P less than 0.01). Libido was not affected and significantly (P less than 0.005) increased numbers of ovulations were noted in immunized animals. These results suggest that immunization of the female rabbit against testosterone may disrupt the normal regulation of follicular maturation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-47
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Effects of active immunization of female rabbits against testosterone.
pubmed:publicationType
Journal Article