Linked Life Data

7448821

Source:http://linkedlifedata.com/resource/pubmed/id/7448821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8-9
pubmed:dateCreated
1981-3-24
pubmed:abstractText
The ability of thioproline to act as a nontoxic inducer of reverse transformation was examined. Thioproline was unable to effect reproducibly morphologic changes characteristic of the reversed transformed state of HeLa, WI-38VA13, C1300 neuroblastoma, and CHO-K1 cell lines. Reversal of transformed cells with dibutyryl cyclic AMP was, however, readily demonstrated in both the CHO-K1 and C1300 cell lines. Thioproline produced severe, life-threatening CNS toxicity in both mice and rats at levels far below those previously reported to be without any toxic effects. We conclude that not only is thioproline incapable of producing a reversal of the transformed state in HeLa and other cell lines in vitro, it is also a compound that must be described as a strongly CNS toxic agent.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-5960
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
837-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Pharmacologic and toxicologic evaluation of thioproline: a proposed nontoxic inducer of reverse transformation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.