Linked Life Data

7448439

Source:http://linkedlifedata.com/resource/pubmed/id/7448439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-3-17
pubmed:abstractText
Taking into account the evolutive features of anaplastic cancers, the authors used four-drug combination chemotherapy with adriamycin, vincristine, methotrexate and cyclophosphamide applied to 55 patients. Treatment was administered in courses of 3 weeks at 15-day intervals and consisted of 3 days of treatment/week, repeated every 15 days. On the whole the treatment was well tolerated; however, the use of adriamycin was restricted because of its cumulative toxicity. Immediate objective responses were observed in 48 patients (87% of the cases) with 32 tumor regressions < 50 per cent (58%), 14 of which were complete remissions. The effects were most distinctive in distant lymph node metastases (78%). In the majority of cases the effects were of brief duration. Whether or not radiotherapy was associated, the overall course of the disease was not significantly influenced. The authors point out that patients responding to this protocol did not achieve the median survival, whereas the median survival was 17 months for an identical period of observation with varied treatments used priorly. The authors conclude that this chemotherapeutic protocol needs to be reinforced and readjusted in order to improve long term results.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0007-4551
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-74
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
[Combination chemotherapy of anaplastic carcinoma with adriamycin, vincristine, methotrexate and cyclophosphamide (author's transl)].
pubmed:publicationType
Journal Article, English Abstract