Linked Life Data

7447553

Source:http://linkedlifedata.com/resource/pubmed/id/7447553

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-2-26
pubmed:abstractText
Specific (3)H-spiroperidol ((3)H-Sp) binding was demonstrated to occur, in vivo, throughout the rat forebrain. The highest concentrations of (3)H-Sp were found in regions known to contain dopamine neuron terminals. Acute and repeated administration of low does of haloperidol decreased in vivo (3)H-Sp in subcortical but not cortical regions. Repeated administration of high does of haloperidol followed by washout periods up to 8 days did not lead to an increase in in vivo (3)H-Sp binding; however, a single dose of d-amphetamine caused substantial increases. Analysis of the alterations induced by haloperidol and d-amphetamine suggest that the dopamine receptor changes configuration upon excessive exposure to agonists or antagonists in such a way as to favor the counterpart ligand.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
246
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
98-107
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effects of haloperidol and d-amphetamine on in vivo 3H-spiroperiodol binding in the rat forebrain(1).
pubmed:publicationType
Journal Article