Linked Life Data

7446214

Source:http://linkedlifedata.com/resource/pubmed/id/7446214

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1981-2-24
pubmed:abstractText
In vitro culture methods are described for mouse embryos during the preimplantation period (Whitten's medium) and for mouse and rat blastocysts during the time of implantation (NCTC-109 medium). Examples are given for the influence of the genetic background (strain differences) on in vitro development and for the detection of a DNA repair mechanism in cultured preimplantation embryos. S-shaped dose effect curves were obtained for the influence of UV-irradiation and cyclophosphamide (CPA) and its metabolites on development of pre implantation mouse embryos treated during in vitro culture. Similar curves were obtained for mouse blastocysts cultured at implantation after treatment of the mother with either CPA or the steroid sex hormones cyproterone acetate (CA) or medroxyprogesterone acetate (MPA). The embryo transplantation technique is described as a teratological method to test the viability of preimplantation mouse embryos which have incorporated the stable isotope 13C during in vitro culture. The importance of the in vitro culture techniques and of the transplantation method in experimental teratology during the earliest period of pregnancy is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6217
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
In vitro methods for the study of the effects of teratogens on preimplantation embryos.
pubmed:publicationType
Journal Article, In Vitro