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pubmed:abstractText |
Serum reverse T3, T3, T4, and TSH concentrations were measured in children with goitre of grade II and III, and in controls of the same age. The average rT3 level was decreased in both goitrous groups and the difference between them was significant. The rT3/T4 ratio in each group changed in a similar way. It seems that in goitre not only the T3 secretion of the thyroid gland is increased but also the deiodination of T4 to T3 increases against rT3, or the degradation and metabolic clearance of T3 and rT3 change.
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