Linked Life Data

7442123

Source:http://linkedlifedata.com/resource/pubmed/id/7442123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-2-26
pubmed:abstractText
We have examined by light and electron microscopy the kidneys of rhesus monkeys infused either with a single bolus of endotoxin (10 mg. per kg.) or continuously at the rate of 10 mg. per kg. per hour for periods of up to 22 hours. Controls included monkeys infused with Ringer's lactate solution. Only minor morphologic changes were seen in animals receiving a bolus of endotoxin. In the animals continuously infused, sequestration of neutrophils and monocytes was observed in the peritubular capillaries and to a lesser extent in the glomeruli. These changes were associated with phagocytosis of endotoxin, occasional fibrin deposits, and extensive endothelial cell damage with focal capillary disruption. Changes found in the advanced stages included prominent interestitial edema with focal necrosis of tubular epithelium. Endothelial cell changes seen in the glomeruli were far less sever than those observed in the peritubular capillaries. Our data indicate that endothelial damage and associated events relating to the sequestration of phagocytic leukocytes primarily involve the peritubular capillaries and that this "inflammatory" process plays a basic role in the development of acute tubular necrosis during shock associated with endotoxemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-32
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Peritubular capillaries. A major target site of endotoxin-induced vascular injury in the primate kidney.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.