Linked Life Data

7441084

Source:http://linkedlifedata.com/resource/pubmed/id/7441084

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1981-2-19
pubmed:abstractText
The purpose of the studies was to examine the acute, chronic, and neoplastic effects of asbestos on mucosa of conducting airways. Heterotopic tracheal grafts were used as the experimental model. In the system employed, the test substance was introduced into the airway lumen and kept in intimate contact with the respiratory tract mucosa for weeks or months. UICC chrysotile A and crocidolite asbestos caused marked acute changes of the tracheal mucosa: epithelial hyperplasia, hypersecretion of mucus, and submucosal inflammation. With chrysotile, the hypersecretory state and goblet cell hyperplasia persisted for many months, resulting in a marked distension of the tracheal grafts. Other manifestations of chronic irritation were focal squamous metaplasias, epithelial erosions, and connective tissue changes involving the tracheal submucosa and adventitia as well as the host subcutaneous tissues. The connective tissue changes were characterized by formation of granulomas, often with necrotic centers. In a 29-month tumor-induction study carried out with chrysotile A, the total tumor incidence in 40 tracheal grafts was 40 percent; this included 2 squamous cell carcinomas (5%)(, and 14 sarcomas (35%) as compared with no carcinomas and 6 sarcomas (12%) in 49 vehicle-treated controls. Thus our studies show that chrysotile (1) causes chronic irritation of the tracheal mucosa, (2) augments sarcoma development, and (3) is a weakly but definitely carcinogenic agent for the respiratory tract mucosa.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0146-4779
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-75
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Toxic and tumorigenic effects of asbestos on tracheal mucosa.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.