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rdf:type |
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lifeskim:mentions |
umls-concept:C0003591,
umls-concept:C0003601,
umls-concept:C0005768,
umls-concept:C0011155,
umls-concept:C0023820,
umls-concept:C0032105,
umls-concept:C0034580,
umls-concept:C0086045,
umls-concept:C0086418,
umls-concept:C0392760,
umls-concept:C0600161
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pubmed:issue |
6
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pubmed:dateCreated |
1981-2-24
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pubmed:abstractText |
A radioimmunoassay for apolipoprotein E in human blood serum has been developed that measures equally the major polymorphic species of the protein (apolipoproteins E-1, E-2, E-3, and E-4) and the apo E in the dimer of apolipoproteins E and A-II. The assay is specific and yields values for apolipoprotein E in very low density lipoproteins that agree closely with those obtained by a quantitative electrophoretic method. Apolipoprotein E is also present in at least one species of high density lipoprotein, but the content of apolipoprotein E in the lipoprotein fractions of plasma is uncertain owing to dissociation during ultracentrifugation. The concentration of apolipoprotein E is higher in serum of normolipidemic, premenopausal women than in men of comparable age and is a direct function of the serum triglyceride level. Apolipoprotein E levels are increased out of proportion to triglyceride levels in hyperlipidemic patients with familial dysbetalipoproteinemia (homozygotes for lack of apolipoprotein E-3). Heterozygous relatives of homozygotes have significantly higher apolipoprotein E levels in serum than unaffected relatives. The concentration of partially degraded (remnant) triglyceride-rich lipoproteins also appears to be increased in heterozygotes, who comprise about 15% of the population.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-13252080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-166665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-169165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-172534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-182242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-182891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-189822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-194587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-194919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-198504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-199847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-200160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-206278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-210174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-215360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-221251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-222259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-226830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-227391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-240514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-4345202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-4352966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-4981584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-5806584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-6933487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-7354059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7440719-759055
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1351-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1980
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pubmed:articleTitle |
Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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