Linked Life Data

7439541

Source:http://linkedlifedata.com/resource/pubmed/id/7439541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1981-2-26
pubmed:abstractText
HLA genotypes have been analyzed in 120 classic type I (insulin-dependent) diabetic sib pairs with an age of onset below 16 yr reported to the British Diabetic Association register (1972--78). By this age, siblings of diabetic children are 26 times more likely to develop type I diabetes than other children. There is a highly significant disturbance in the zygotic assortment of HLA haplotypes in these sib pairs, providing conclusive evidence for the existence of major susceptibility genes in the HLA complex. The present data exclude a simple dominant or recessive model of inheritance. It is likely that both parents contribute to the susceptibility, indicating the presence of two HLA-linked genes (or clusters of genes in linkage disequilibrium) that influence the predisposition to the disease. There is no evidence that type I diabetic multiplex families have an increased HLA risk or increased predisposition to autoimmunity compared with families with one affected child.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1036-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Type I (insulin-dependent) diabetic multiplex families: mode of genetic transmission.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't