Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1981-2-19
|
| pubmed:abstractText |
The results of in vitro fertilization of mature oocytes obtained at diagnostic laparoscopy from patients with both known and unknown clinical causes of infertility are presented. A simple regimen involving the use of clomiphene and human chorionic gonadotropin which enabled laparoscopy to coincide with available surgical lists resulted in the recovery of mature oocytes from 15 of the 18 patients treated. Apparently normal embryos developed from five of six oocytes recovered from patients who had blocked fallopian tubes or who were being investigated after 8 to 12 months of artificial insemination by donor. No normal embryos developed from oocytes from nine patients who had sustained infertility of unknown cause for 2 years or more. When this latter group was compared with other groups a high rate of fertilization failure was noted, and severe polyspermy developed in two cases. The results are discussed in relation to the diagnosis of infertility and the management of infertile patients.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Artificial Insemination,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Clomiphene--administraction and...,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Fertilization,
http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins,
http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins...,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/In Vitro,
http://linkedlifedata.com/resource/pubmed/keyword/Infertility,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Control Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0015-0282
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
431-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:otherAbstract |
PIP: This study examines the use of in vitro fertilization as a diagnostic procedure for patients with long-term infertility of unknown cause (idiopathic infertility). 18 infertile patients participated in the study and included: 1) 5 patients with occluded fallopian tubes who served as controls; 2) 3 patients who failed to become pregnant after 8 to 12 months of AID (artificial insemination by donor); and 3) 10 patients who had not conceived in spite of 2 years of regular unprotected coitus (those with idiopathic infertility). Clomiphene citrate and human chorionic gonadotropins (hCG) were administered to control follicular development and maturation to coincide with time of laparoscopy. 25 mature oocytes were extracted from 15 out of the 18 patients at laparoscopy. In vitro fertilization was performed by adding washed spermatozoa to culture tube containing oocyte-cumulus mass and then incubating the culture. Embryo development occurred in the oocytes of 5 of 6 patients who had blocked fallopian tubes and who had AID. No normal embryos developed in the oocytes of 9 patients with idiopathic infertility. Furthermore, fertilization failures and oocyte abnormalities were higher in this group than in the other 2 groups. Clinical recommendations for managing the 3 groups of infertile patients were discussed. Further research should be done on the long-term infertility of unknown cause.
|
| pubmed:meshHeading |
pubmed-meshheading:7439409-Embryo, Mammalian,
pubmed-meshheading:7439409-Fallopian Tubes,
pubmed-meshheading:7439409-Female,
pubmed-meshheading:7439409-Fertilization in Vitro,
pubmed-meshheading:7439409-Humans,
pubmed-meshheading:7439409-Infertility, Female,
pubmed-meshheading:7439409-Insemination, Artificial, Heterologous,
pubmed-meshheading:7439409-Oocytes,
pubmed-meshheading:7439409-Pregnancy
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
The investigation of idiopathic infertility by in vitro fertilization.
|
| pubmed:publicationType |
Journal Article
|