Linked Life Data

7438563

Source:http://linkedlifedata.com/resource/pubmed/id/7438563

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-2-26
pubmed:abstractText
The intradermal injection into rabbits of various phagocytosible materials is known to induce polymorphonuclear leucocyte infiltration, protein exudation and microvascular haemorrhage. The injection of rabbit plasma, in which complement is activated with zymosan, also induces polymorphonuclear leucocyte infiltration. We investigated the effect of this soluble, non-ingestible stimulus to polymorphonuclear leucocyte accumulation on vascular integrity. Vascular permeability, measured with 125I-human serum albumin, was markedly but only transiently increased 1 hr after zymosan-activated plasma injection. In contrast, haemorrhage or red blood cell extravasation, measured with 59Fe-labelled red cells, developed only 4 hr after zymosan-activated plasma injection and continued for at least 10 hr. A direct correlation was found between the number of infiltrating polymorphonuclear leucocytes as measured with 51Cr-labelled leucocytes, and the degree of haemorrhage. Histological sections confirmed these changes. Plasma that was heat-inactivated (56 degrees C, 30 min) or made functionally C5-deficient prior to zymosan activation, failed to induce haemorrhage and caused no, or only mild , leucocyte infiltration. It is postulated that the C5ades arg in zymosan-activated plasma not only induces polymorphonuclear leucocyte infiltration but also, directly or indirectly, causes microvascular damage.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
505-11
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Enhanced vascular permeability and haemorrhage-inducing activity of zymosan-activated plasma.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't