Linked Life Data

7438033

Source:http://linkedlifedata.com/resource/pubmed/id/7438033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1981-2-26
pubmed:abstractText
We previously have reported that glucose deprivation specifically enhance cell killing by hyperthermia in the absence of oxygen. The present studies were carried out to evaluate the interplay of glucose and oxygen on cell killing by hyperthermia (37 to 42 degrees) for up to 4 hr under varying concentrations of glucose (0 to 1 mg/ml) and oxygen (0 to 21%). pH 7.4 was maintained in all trials. In the absence of oxygen, enhanced cell killing at 40 and 42 degrees was seen with glucose concentrations below 0.1 and 0.25 mg/ml of media, respectively. In the absence of glucose, enhanced killing was seen when oxygen concentrations were below 1 and 2% at 40 and 42 degrees, respectively. The radiosensitivity of the cells was influenced only by the oxygen concentration during irradiation and not by glucose. These results indicate that oxygen and glucose are important modifying factors of cell lethality by hyperthermia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3459-62
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Selective killing of glucose and oxygen-deprived HeLa cells by hyperthermia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.