Linked Life Data

7436888

Source:http://linkedlifedata.com/resource/pubmed/id/7436888

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-1-29
pubmed:abstractText
Mannose and glucosamine-containing oligosaccharides were extracted from tissues of variously aged calves with mannosidosis. Whereas storage in the brain, and to a lesser extent in the pancreas and lymph nodes, was cumulative, that in the liver was relatively stable over the time period followed. It is suggested that in this latter organ the 15--20% residual alpha-mannosidase activity attributable to the mutant enzyme might be sufficient to normalise function. In the kidney, levels actually fell over the first 15--20 weeks of life and thereafter remained constant. It is postulated that, in foetal life, storage is cumulative but, after birth, storage material is lost from the kidney into the urine by degeneration and/or desquamation of renal tubular cells. From 20 weeks the amount lost is in equilibrium with that formed or absorbed by the tubular cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0004-945X
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
421-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Mannosidosis: patterns of storage and urinary excretion of oligosaccharides in the bovine model.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.