Linked Life Data

7432471

Source:http://linkedlifedata.com/resource/pubmed/id/7432471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5781
pubmed:dateCreated
1981-1-16
pubmed:abstractText
Endogenous avian and murine C-type viruses are genetic elements which are transmitted at several distinct chromosomal loci. Different patterns of virus activation have been observed in a variety of different mouse strains. However, because there are multiple copies of closely related endogenous viruses in every mouse strain, the genetic basis of the differential expression of these genes is poorly understood. A new substrain of mice, BALB/Mo, was derived previously carrying the exogenous Moloney leukaemia virus (M-MuLV) genome on chromosome 6 (ref. 14). Virus activation occurs in lymphatic tissues of all BALB/Mo mice soon after birth. We report here the derivation of three new substrains of mice each carrying a single M-MuLV genome on different chromosomal integration sites. Each locus was associated with a distinct phenotype of virus expression. Evidence is presented that apparently identical viral genomes show differences in spontaneous virus activation and that defective viral genomes can be carried in the germ line of mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
287
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
456-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't