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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1981-1-26
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pubmed:abstractText |
Lethal enterocolitis was induced in guinea pigs by intramuscular injection of penicillin. The presence of filterable toxic substance in the cecal contents of penicillin-treated guinea pigs was demonstrated. The toxin was heat-labile and produced enterosorption activity in rabbit intestinal loops and morphologic changes in Y-1 adrenal cell cultures. The cecal filtrates were lethal for mice when injected intraperitoneally and lethal for guinea pigs when injected intraperitoneally or intracecally. Cecal filtrates from saline-treated guinea pigs were not lethal to experimental animals. Filtrates prepared from broth cultures of cecal contents from penicillin or saline-treated guinea pigs also showed the presence of a lethal toxic substance. The study demonstrated that bacteremia is minimal, nonspecific and probably a terminal event in penicillin-associated deaths in guinea pigs.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
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pubmed:issn |
0023-6764
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
524-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7431852-Animals,
pubmed-meshheading:7431852-Biological Assay,
pubmed-meshheading:7431852-Blood,
pubmed-meshheading:7431852-Cecum,
pubmed-meshheading:7431852-Cells, Cultured,
pubmed-meshheading:7431852-Colitis,
pubmed-meshheading:7431852-Guinea Pigs,
pubmed-meshheading:7431852-Mice,
pubmed-meshheading:7431852-Penicillins,
pubmed-meshheading:7431852-Rabbits,
pubmed-meshheading:7431852-Rodent Diseases,
pubmed-meshheading:7431852-Toxins, Biological
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pubmed:year |
1980
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pubmed:articleTitle |
Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|