Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-1-26
pubmed:abstractText
Lethal enterocolitis was induced in guinea pigs by intramuscular injection of penicillin. The presence of filterable toxic substance in the cecal contents of penicillin-treated guinea pigs was demonstrated. The toxin was heat-labile and produced enterosorption activity in rabbit intestinal loops and morphologic changes in Y-1 adrenal cell cultures. The cecal filtrates were lethal for mice when injected intraperitoneally and lethal for guinea pigs when injected intraperitoneally or intracecally. Cecal filtrates from saline-treated guinea pigs were not lethal to experimental animals. Filtrates prepared from broth cultures of cecal contents from penicillin or saline-treated guinea pigs also showed the presence of a lethal toxic substance. The study demonstrated that bacteremia is minimal, nonspecific and probably a terminal event in penicillin-associated deaths in guinea pigs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0023-6764
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
524-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Toxicity of cecal filtrates from guinea pigs with penicillin-associated colitis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't