Linked Life Data

7431128

Source:http://linkedlifedata.com/resource/pubmed/id/7431128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1981-1-26
pubmed:abstractText
An investigation was undertaken to study the effect of trans isomers of octadecenoic (18:1) and octadecadienoic (18:2) acids on serum lecithin:cholesterol acyltransferase (LCAT). Male rats of the Wistar strain were fed diets containing 15% fat for 9 months. The fat diets were either hydrogenated fat mixtures containing trans fatty acids, corn oil or lard. At the end of 9 months, rats were killed and serum cholesterol levels and LCAT activity were measured. It was found that free and total serum cholesterol levels were decreased when animals were fed trans fatty acids when compared with animals fed corn oil or lard. Although in vitro studies indicated that the percentage of cholesterol esterified in serum was not affected by the presence of dietary trans fatty acids, LCAT activity generally decreased when trans fatty acids were fed to rats for 9 months. In this study a negative correlation was found between serum free cholesterol and LCAT activity. Depressed total LCAT activity (mumoles of cholesterol esterified per hour per liter of serum) may have been related to a reduced amount of substrate (free cholesterol).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2284-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of trans fatty acids on serum lecithin: cholesterol acyltransferase in rats.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't