Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-1-16
pubmed:abstractText
A variant subline (B16-F10-B2) selected from the B16-F10 melanoma cell line, shows greater metastatic capacity and preferential growth in the brain after i.v. injection into C57BL/6 mice. Several biological properties of these two cell lines have been compared, in an effort to determine the mechanisms responsible for this non-random metastatic pattern. No differences in cell morphology, in vitro growth rates or exposed cell-surface proteins were detected. Quantitative analysis of tumour-cell arrest and distribution using 125IUdR-labelled cells indicated that, although initial arrest patterns of the cell lines were very similar, B16-F10-B2 cells survived in the lungs to a greater cell line had a higher mean number of chromosomes than the parent line, whereas the variance of chromosome distribution was less. We suggest that the selection of a brain-colonizing variant represents the emergence of a pre-existing subpopulation of cells, and provides a useful model for studying mechanisms of intracranial metastasis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-1161258, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-1203029, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-14114974, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-14159805, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-354778, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-360795, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-427739, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-4412796, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-4512654, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-468414, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-4842910, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-4912327, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-5131013, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-544929, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-5475483, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-5513503, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-6251508, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-665907, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-692661, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-6929000, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-7370995, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-887927, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-894752, http://linkedlifedata.com/resource/pubmed/commentcorrection/7426339-900904
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-41
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Murine melanoma: a model for intracranial metastasis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.