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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-1-16
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pubmed:abstractText |
1 Single dose studies of theophylline kinetics were compared in groups of young and elderly smokers and non-smokers to assess the effect of age on theophylline absorption and the effect of smoking on drug metabolising enzyme activity in old age. 2 The rate and extent of absorption was not affected by age. Distribution and elimination kinetics were similar in young and elderly non-smokers. 3 In young subjects the elimination half-life of theophylline was shorter and clearance was significantly greater in smokers than in non-smokers. 4 In the elderly mean elimination half-life was significantly shorter in smokers and their plasma clearance was 40% higher than in non-smokers. The statistical difference for clearance was at the 7% level of significance. 5 These data indicate that ageing per se does not affect theophylline elimination and also that induction of theophylline metabolism due to smoking occurs in old age. Smoking is a variable that should be taken account of when assessing drug metabolism in elderly patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-1128573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-1164824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-1233203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-1277710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-13475320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-14201126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-15422233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-349132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-4299573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-4396729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-444368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-445943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-5569980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-580350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-630791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-630795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-630961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-665427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-677562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-688731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-692577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-697173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-720377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-797500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-805710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-81408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-837650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-879596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-890391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7426272-925190
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0306-5251
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-14
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
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pubmed:year |
1980
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pubmed:articleTitle |
Theophylline kinetics in relation to age: the importance of smoking.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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