Linked Life Data

7425866

Source:http://linkedlifedata.com/resource/pubmed/id/7425866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-12-18
pubmed:abstractText
Microsomes prepared from the brachial artery and the thoracic aorta of atherosclerosis resistant (AR) Show Racer and atherosclerosis prone (AS) White Carneau pigeons were incubated with 14C-prostaglandin endoperoxide (PGH) and prostaglandin products analyzed. The microsomes demonstrated minimal prostacyclin (PGI2) synthetase activity; 6-keto-PGF1 alpha (the hydrolytic breakdown product of PGI2) accounting for less than 2% of total products. Reduced glutathione enhanced PGE2 formation in both the AR and AS preparations identifying an active PGH-PGE isomerase. The AR preparations demonstrated increased PGH-PGE formation with age, reaching maximal activity at 8-9 months, then decreasing at 14 months. The AS group also demonstrated a similar pattern of enzyme activity. These studies indicate that a) unlike the mammalian preparations prostacyclin synthetase does not appear to be a major enzymatic activity of the pigeon aorta, rather, b) PGH-PGE isomerase is the major endoperoxide metabolizing activity in the pigeon aorta and thus, c) a deficiency of prostacyclin production is not involved in the geneis of atherosclerosis in the pigeon.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-6127
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Prostaglandin E2 synthesis in pigeon aorta: comparison of atherosclerosis-resistant (Show Racer) and atherosclerosis-prone (White Carneau) breeds.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.