Linked Life Data

742557

Source:http://linkedlifedata.com/resource/pubmed/id/742557

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1979-4-28
pubmed:abstractText
High (500 microgram) and low (100 microgram) doses of carrageenin produced different temporal extravasation of plasma protein when injected into the rat paw. High doses caused a continuous extravasation parallel to the oedema increase. With low doses, main exudation occurred during the first 2 h and was minimal when the oedema was maximal (4th hour). Pre-treatment with indomethacin (2 mg/kg/i.p.) was effective in reducing oedema and protein extravasation for both doses of carrageenin. Indomethacin given 2 h after carrageenin had no effect upon the oedema caused by the low doses, but was effective with the high doses of carrageenin. The anti-oedematogenic effect of a non-steroid anti-inflammatory agent, such as indomethacin, was related to its effect upon plasma exudation, i.e. the agent was effective when there was a correlation between increment of oedema and plasma extravasation. The continuously increased plasma extravasation indicated the continuous presence of an active damaging stimulus. Our results explain several apparently contradictory observations reported in the literature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0065-4299
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
606-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Relationship between oedema and plasma exudation in rat paw carrageenin inflammation.
pubmed:publicationType
Journal Article