Linked Life Data

7422055

Source:http://linkedlifedata.com/resource/pubmed/id/7422055

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1980-12-16
pubmed:abstractText
The glycerophospholipid (GPL) content and acyl group compositions of isolated brain endothelial fractions have been determined in the developing rat. During development there is a marked change in the proportions of ethanolamine glycerophospholipids (EGP) to choline glycerophospholipids (CGP), the former rising while CGP falls with age. The acyl group compositions of plasmenylethanolamine (P-GPE) and 1,2-diacyl-sn-glycero-3-phosphocholine (D-GPC) after significantly during development; both show a decline in saturated fatty acids (SFAs) and a rise in the n-6/SFA ratio, in contrast to a constancy in composition of 1,2-diacyl-sn-glycero-3-phosphoethanolamine (D-GPE). The degree of change in the acyl group composition in a particular GPL fraction is related to the rate of its accumulation and to the proportional increase in concentration, fractions accumulating most rapidly or increasing markedly in concentration showing the greatest acyl group compositional change. The possible significance of the high proportion of SFAs in P-GPE and D-GPC fractions in the developing brain endothelial fraction is discussed in relation to the altering blood-brain barrier capacities observed with age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0364-3190
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
683-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Changes in the content and acyl group composition of glycerophospholipids of brain endothelial cells of the developing rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't