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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5782
|
| pubmed:dateCreated |
1980-12-16
|
| pubmed:abstractText |
Image reconstruction to 22 A resolution of the histone octamer (H3)2(H4)2(H2A)2(H2B)2 shows it to have a 2-fold axis of symmetry, and the overall shape of the left-handed helical spool on which to wind about two turns of a flat superhelix of DNA in the nucleosome. From this structure and the results of various cross-linking studies, we have deduced the arrangement of the individual histones. We propose that the (H3)2(H4)2 tetramer forms a dislocated disk which defines the central turn of DNA, while the two H2A-H2B dimers lie one on each face, each associated with about one half a turn.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
287
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
509-16
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7422003-Animals,
pubmed-meshheading:7422003-Cross-Linking Reagents,
pubmed-meshheading:7422003-Crystallography,
pubmed-meshheading:7422003-DNA,
pubmed-meshheading:7422003-Histones,
pubmed-meshheading:7422003-Liver,
pubmed-meshheading:7422003-Nucleosomes,
pubmed-meshheading:7422003-Protein Binding,
pubmed-meshheading:7422003-Rats
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
A low resolution structure for the histone core of the nucleosome.
|
| pubmed:publicationType |
Journal Article
|